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RETINOBLASTOMA GENES
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DeCS
Descriptor
English
:
Genes, Retinoblastoma
Descriptor
Spanish
:
Genes de Retinoblastoma
Descriptor
Portuguese
:
Genes do Retinoblastoma
Synonyms
English
:
Genes, Rb
Rb Genes
Retinoblastoma Genes
Tree Number:
G05.360.340.024.340.375.249.400
G05.360.340.024.340.415.400.400
Definition
English
:
Tumor suppressor genes located on human
chromosome 13
in the region 13q14 and coding for a
family
of
phosphoproteins
with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both
alleles
at this locus results in
retinoblastoma.
See Related
English
:
Retinoblastoma
History Note
English
:
91
Allowable Qualifiers
English
:
DE
drug effects
ES
ethics
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
28960
Unique Identifier:
D016161
Occurrence in VHL
:
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DeCS
CID-10
SciELO
LILACS
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